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Watch Intently (1)pentobarbital will improve the stage or influence of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with strong CYP3A4 inducers; these drugs lower publicity t